Ethanone, 2-chloro-1-[2-[[3-(trifluoromethyl)phenyl]amino]phenyl]-
2-Chloro-1-(2-((3-(trifluoromethyl)phenyl)amino)phenyl)ethan-1-one
CAS: 2378626-29-8
Molecular Formula: C15H11ClF3NO
Ethanone, 2-chloro-1-[2-[[3-(trifluoromethyl)phenyl]amino]phenyl]- - Names and Identifiers
Ethanone, 2-chloro-1-[2-[[3-(trifluoromethyl)phenyl]amino]phenyl]- - Physico-chemical Properties
| Molecular Formula | C15H11ClF3NO |
| Molar Mass | 313.7 |
| Density | 1.352±0.06 g/cm3(Predicted) |
| Boling Point | 378.0±42.0 °C(Predicted) |
| Solubility | Soluble in DMSO |
| pKa | -2.67±0.50(Predicted) |
| Storage Condition | -20℃ |
| Use | TED-347 is a covalent inhibitor of TEAD4-Yap1 protein-protein interaction in mammalian cells which blocks iTEAD transcriptional activity and inhibits glioblastoma cell viability. |
Ethanone, 2-chloro-1-[2-[[3-(trifluoromethyl)phenyl]amino]phenyl]- - Reference
| Reference Show more | 1. Khuchtumur Bum-Erdene, et al. Small-Molecule Covalent Modification of Conserved Cysteine Leads to Allosteric Inhibition of the TEAD⋅Yap Protein-Protein Interaction. Cell Chem Biol. 2019 Mar 21;26(3):378-389.e13. |
Ethanone, 2-chloro-1-[2-[[3-(trifluoromethyl)phenyl]amino]phenyl]- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.188 ml | 15.939 ml | 31.878 ml |
| 5 mM | 0.638 ml | 3.188 ml | 6.376 ml |
| 10 mM | 0.319 ml | 1.594 ml | 3.188 ml |
| 5 mM | 0.064 ml | 0.319 ml | 0.638 ml |
Last Update：2024-01-02 23:10:35
Ethanone, 2-chloro-1-[2-[[3-(trifluoromethyl)phenyl]amino]phenyl]- - Reference Information
| biological activity | TED-347 is an effective and irreversible covalent allosteric inhibitor of the TEDLYap protein-protein interaction. TED-347 can inhibit TEAD4 Yap1 protein interaction with an EC50 value of 5.9 μM. |
| target | TargetValue TEAD4 Lap1 (Cell-free say) 5.9 μM(EC50) |
| Target | Value |
| TEAD4 Yap1 (Cell-free assay) | 5.9 μM(EC50) |
Last Update：2024-04-09 21:04:16
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Product Name: 2-Chloro-1-(2-((3-(trifluoromethyl)phenyl)amino)phenyl)ethan-1-one Visit Supplier Webpage Request for quotationCAS: 2378626-29-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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